Hydroxychloroquine makes a comeback in new study

[GoodLife]

It must have been very painful for CNN to release this news. (maybe that's why they released it at 4:30 am this morning)

A lot of people thought this drug was killed off by previous VA study and another one that was published in The Lancet and then withdrawn because of data fraud.

Study finds hydroxychloroquine helped coronavirus patients survive better

A team at Henry Ford Health System in Southeast Michigan said Thursday its study of 2,541 hospitalized patients found that those given hydroxychloroquine were much less likely to die.

Dr. Marcus Zervos, division head of infectious disease for Henry Ford Health System, said 26% of those not given hydroxychloroquine died, compared to 13% of those who got the drug. The team looked back at everyone treated in the hospital system since the first patient in March.

Study finds hydroxychloroquine helped coronavirus patients survive better (https://www.msn.com/en-us/health/medical/study-finds-hydroxychloroquine-helped-coronavirus-patients-survive-better/ar-BB16hifu)

It's an observational study, so not the gold standard double blind clinical type that is really needed, but those are coming soon, both for treating the infected and as a prophylactic. There are some problems noted about this study as is usual with an observational type study. They also did not report any cardiac problems.

[TexaninVA]

It must have been very painful for CNN to release this news. (maybe that's why they released it at 4:30 am this morning)

A lot of people thought this drug was killed off by previous VA study and another one that was published in The Lancet and then withdrawn because of data fraud.

Study finds hydroxychloroquine helped coronavirus patients survive better

A team at Henry Ford Health System in Southeast Michigan said Thursday its study of 2,541 hospitalized patients found that those given hydroxychloroquine were much less likely to die.

Dr. Marcus Zervos, division head of infectious disease for Henry Ford Health System, said 26% of those not given hydroxychloroquine died, compared to 13% of those who got the drug. The team looked back at everyone treated in the hospital system since the first patient in March.

Study finds hydroxychloroquine helped coronavirus patients survive better (https://www.msn.com/en-us/health/medical/study-finds-hydroxychloroquine-helped-coronavirus-patients-survive-better/ar-BB16hifu)

It's an observational study, so not the gold standard double blind clinical type that is really needed, but those are coming soon, both for treating the infected and as a prophylactic. There are some problems noted about this study as is usual with an observational type study. They also did not report any cardiac problems.

By denying the benefits of this drug, just because you know who touted it, is a good example of the underlying psychology of cutting off one's nose to spite one's face etc

Amazing to watch this debate ... I think it's mainly another way for people to express their hatred masked as medically objective blah blah blah

[John41]

Very sad that politics enters into medicine.

[DonH57]

Very sad that politics enters into medicine.

I agree.:ohdear:

[MandoMan]

This paragraph in the article might be significant: “ Finally, concomitant steroid use in patients receiving hydroxychloroquine was more than double the non-treated group. This is relevant considering the recent RECOVERY trial that showed a mortality benefit with dexamethasone." The steroid dexamethasone can reduce inflammation in seriously ill patients.” So maybe it’s the cortisone that is helping.

It must have been very painful for CNN to release this news. (maybe that's why they released it at 4:30 am this morning)

A lot of people thought this drug was killed off by previous VA study and another one that was published in The Lancet and then withdrawn because of data fraud.

Study finds hydroxychloroquine helped coronavirus patients survive better

A team at Henry Ford Health System in Southeast Michigan said Thursday its study of 2,541 hospitalized patients found that those given hydroxychloroquine were much less likely to die.

Dr. Marcus Zervos, division head of infectious disease for Henry Ford Health System, said 26% of those not given hydroxychloroquine died, compared to 13% of those who got the drug. The team looked back at everyone treated in the hospital system since the first patient in March.

Study finds hydroxychloroquine helped coronavirus patients survive better (https://www.msn.com/en-us/health/medical/study-finds-hydroxychloroquine-helped-coronavirus-patients-survive-better/ar-BB16hifu)

It's an observational study, so not the gold standard double blind clinical type that is really needed, but those are coming soon, both for treating the infected and as a prophylactic. There are some problems noted about this study as is usual with an observational type study. They also did not report any cardiac problems.

[karostay]

Very sad that politics enters into medicine.

Not to mention every aspect of our lives

[Hoosierb4]

This was a "retrospective study", a kind of study that is frequently, although not intentionally biased. Not comparable to a double blinded trial, which is required for drug approval. It is biased because the group who received the drug was chosen, based on criteria that the doctors used to determine who would receive it and who would not. For example, it would have excluded patients with cardiac problems which would have been aggravated by the drug (a known side effect). This kind of study is easy to conduct, but can lead to comparing apples and oranges. We'll have to wait for double blinded studies to be completed before we know for sure whether it works. Meanwhile, there will be other drugs (probably monoclonal antibodies) that will be found to be better.

[GoodLife]

This paragraph in the article might be significant: “ Finally, concomitant steroid use in patients receiving hydroxychloroquine was more than double the non-treated group. This is relevant considering the recent RECOVERY trial that showed a mortality benefit with dexamethasone." The steroid dexamethasone can reduce inflammation in seriously ill patients.” So maybe it’s the cortisone that is helping.

Yes I noticed that. There have been some good reports on that drug by itself but I think it just shortened hospital stays like remdesivir. Also could mean the combo works good together.

[Byte1]

Gotta laugh at those certain political figures that declared it to be a very dangerous drug that should not be used. If it was so dangerous, why did they give it to EVERY soldier that fought in the jungles of Vietnam? Of course it didn't/doesn't work on everyone. I have a friend that took his religiously and still ended up with malaria that put him in the hospital. I didn't take it at all and didn't catch malaria, but that just means that everyone is different. Seems to me if one is willing to wear a mask because they think that it will protect them, then they would be open minded enough to take a SAFE drug that someone/doctors says might keep them alive.

[NotFromAroundHere]

If it was so dangerous, why did they give it to EVERY soldier that fought in the jungles of Vietnam?

REALLY? That's your argument? It must be safe because they gave to guys in Vietnam?

[Bay Kid]

No money for their buddies in hydroxychloroquine. If you know who said it didn't work then they would want it.

[Bonnevie]

REALLY? That's your argument? It must be safe because they gave to guys in Vietnam?

not to mention the same people also sprayed Agent Orange on them.....

[Bonnevie]

what people don't realize, hydroxy was used....you read reports of it being used in NYC. believe me, they would have tried anything to save patients and you do not need an FDA indication to use the drug. it can be used "off label" any time a dr. wants. if it was the miracle drug the results would be less fuzzy.

[roscoguy]

Study finds hydroxychloroquine helped coronavirus patients survive better

A team at Henry Ford Health System in Southeast Michigan said Thursday its study of 2,541 hospitalized patients found that those given hydroxychloroquine were much less likely to die.

Dr. Marcus Zervos, division head of infectious disease for Henry Ford Health System, said 26% of those not given hydroxychloroquine died, compared to 13% of those who got the drug. The team looked back at everyone treated in the hospital system since the first patient in March.

Study finds hydroxychloroquine helped coronavirus patients survive better (https://www.msn.com/en-us/health/medical/study-finds-hydroxychloroquine-helped-coronavirus-patients-survive-better/ar-BB16hifu)

They also did not report any cardiac problems.

It is also important to note: "The combination of hydroxychloroquine plus azithromycin was reserved for selected patients with severe COVID-19 and with minimal cardiac risk factors," the team wrote." Maybe that's why no reported cardiac problems?

[GoodLife]

what people don't realize, hydroxy was used....you read reports of it being used in NYC. believe me, they would have tried anything to save patients and you do not need an FDA indication to use the drug. it can be used "off label" any time a dr. wants. if it was the miracle drug the results would be less fuzzy.

It has to be used at the right time, like before you are on a ventilator. That's why it failed in the VA test.

[GoodLife]

It is also important to note: "The combination of hydroxychloroquine plus azithromycin was reserved for selected patients with severe COVID-19 and with minimal cardiac risk factors," the team wrote." Maybe that's why no reported cardiac problems?

The whole "hydroxychloroquine is dangerous" story is a farce. Millions of people take it every day with no problems. If used with azithromycin the combo can cause heart arrythmias, but they can use another antibiotic which is safer. Any Doctor that might prescribe these drugs will take a look at your heart data and decide if safe. Standard practice.

We never heard that HCQ was dangerous until you know who talked about it.

[roscoguy]

The whole "hydroxychloroquine is dangerous" story is a farce. Millions of people take it every day with no problems. If used with azithromycin the combo can cause heart arrythmias, but they can use another antibiotic which is safer. Any Doctor that might prescribe these drugs will take a look at your heart data and decide if safe. Standard practice.
How did you decide that the reported danger is a farce? There are many studies with widely varying observations, none are definitive as yet. Besides, if there was no danger, why did the Ford study carefully screen out patients with cardiac risks?
You like this study & toss out others, but NIH ended their clinical trial (big difference, as I'm sure you are aware), reporting "treatment does no harm, but provides no benefit." NIH halts clinical trial of hydroxychloroquine | National Institutes of Health (NIH) (https://www.nih.gov/news-events/news-releases/nih-halts-clinical-trial-hydroxychloroquine)
We never heard that HCQ was dangerous until you know who talked about it.There actually isn't a conspiracy under every stone, sometimes there are just worms... :ohdear: