Talk of The Villages Florida - Rentals, Entertainment & More
Talk of The Villages Florida - Rentals, Entertainment & More
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New study on Hydroxychloroquine with Azithromycin, failure
There have been many threads pushing hydroxychloroquine with and without azithromycin. This combination has been touted by many here and by some elsewhere as having been proven. I have participated in the TOTV threads cautioning that the data are not clear and more studies are being done.
One is now ready for publication. Like the one that started it all, this is from France. It looked at 11 patients in Paris to attempt to replicate the earlier study where it was claimed that 6 of 6 patients given the combination had no virus detected after 6 days from the start of therapy. Exactly the same drugs and doses were used. Quote:
The authors' conclusion: Quote:
Also note that 1 of 11 had to have the medication stopped because of unexpected cardiac changes putting him or her at risk for sudden death after just a few doses. These medications are not without risk.
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Men plug the dikes of their most needed beliefs with whatever mud they can find. - Clifford Geertz |
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#2
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Good review, thank you.
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#3
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__________________
"No one is more hated than he who speaks the truth." Plato “To argue with a person who has renounced the use of reason is like administering medicine to the dead.” Thomas Paine |
#4
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Eleven patients does not make for a large study to prove or disprove anything and I am sure that is the point you are making.
We all are clutching at straws. Hoping for a vaccine sooner than predicted. Stay safe, Doctor. I like to debate you on politics but highly respect your medical experience and knowledge.
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It is better to laugh than to cry. |
#5
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I like Dr Oz.
I assume if BlueAsh gets the virus he will refuse the Hydroxychloroquine. If I get it I will welcome anything that won't kill me. Last edited by skyking; 04-02-2020 at 09:27 AM. |
#6
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This one shows benefit, from Wuhan China
And today a new study. This out of China so some of you don't believe anything out of China can ignore this one, unless of course it fits your preconceived ideas.
Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial | medRxiv This study was randomized with a control group. It has not been peer reviewed. It was done on patients with mild disease, not severe disease. Quote:
Quote:
Also note that the only statistically significant benefit was in time to decrease fever and cough. The difference in chest findings tended to favor HCQ but was not statistically significant. As to the personal attacks at me for actually posting the studies and their findings. I have posted every single one I have found, both those that show benefit and those that failed. It is about 50/50 at this time. It you already have your mind made up you have my permission to stop reading my posts about the studies. I don't have my mind made up because the data is not clear and the science is not established. Some people have open and inquisitive minds and are amenable to change based on evidence. Some people don't.
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Men plug the dikes of their most needed beliefs with whatever mud they can find. - Clifford Geertz |
#7
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And as you are a reliable reader I'll digress here to explain culture vs. PCR. In the cultures done in the French studies, a sample is taken then incubated with live cells. If there is virus present those cells are disrupted and this alteration is visually confirmed by microscope. In pcr testing the presence of the RNA [like DNA] known to exist in the virus is measured. PCR is what the labs are using in large scale testing. This distinction is potentially important. A viral culture proves that the virus is still active and capable of attacking cells. While a virus is not "alive" that is a reasonable analogy. On the other hand, a positive PCR could occur if inactive viral particles are present which still have RNA intact but are no longer capable of causing disease. There are animal and human studies showing that the PCR stays positive after the culture becomes negative in other corona virus diseases. You can read about them in the Lancet Quote:
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Men plug the dikes of their most needed beliefs with whatever mud they can find. - Clifford Geertz |
#8
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blueish, thanks for the posts. Ignore the personal attacks. We already know the outcome of assuming.
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Humility is not thinking less of yourself, its thinking of yourself less. |
#9
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Sure enough. Mrs Blueash asks what I'm doing on the laptop. I just tell her "pie fights"
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Men plug the dikes of their most needed beliefs with whatever mud they can find. - Clifford Geertz |
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It's harder to hate close up. |
#12
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When you start with the hypothesis that it's 100% effective, then a single failure to be effective - crumbles that hypothesis and renders it categorically false. |
#13
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???? Where did anyone say it was 100% effective? Very few medications are.
So you are saying that it is 100% ineffective? That's a false assumption. Also the drug has been around since 1955. Any adverse effects are well known. |
#14
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Quote:
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"Life should NOT be a journey to the grave with the intention of arriving safely in an attractive and well preserved body, but rather to skid in sideways, cigar in one hand, bourbon in the other, body thoroughly used up, totally worn out and screaming "WOO HOO - what a ride!" -- Hunter S. Thompson |
#15
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I agree. Thank you for your professional, unbiased messages. The fact that you take the time to post shows that you care about others.
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Closed Thread |
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