We had been wanting to go there for years and years ever since I heard about the inn on the lake. While visiting in the Villages for the month of November one year , we took a ride over. Although the lake was nice, as was the lake drive in Tavares.......we were not impressed at all with the town of Mount Dora. It had been advertised as the "New England of Florida."

Just didn't "get it" at all.......didn't see any shops open actually.......
The inn really wasn't on the lake either......didn't see any "bustling" tourism either. It was kind of dead.

It might be a difficult town to push a wheelchair......but just my opinion.

I'd stay in THE VILLAGES where the sidewalks and restaurants and the boardwalk on Lake Sumter Landing are more wheelchair friendly. Ditto for the various squares.....

She might like the town of Tarpon Springs which has a lot of Greek restaurants and the old sponge docks in town..........west coast of Florida.
I think Tarpon Springs has a lot more going for it than does Mount Dora.
Nice homes on meandering lagoon like canals/river....etc. Park like, with the big old oak trees.

Is it open all year long?

Yes, I'm sure Homossassa Wildlife Park is open all year long. It is really a wonderful spot for old and young. You can get a boat ride, wheelchair accessible or tram ride. It's reasonable, easy to get to with diverse animals and cooling shade in most of the areas.