We have been using Trifexis on our Mastiff with virtually no problems. It's an oral and they apparently don't taste good but my wife always gets her to take it without a lot of wrangling.

[ame=http://www.amazon.com/Frontline-Tritak-3pk-Large-Dogs/product-reviews/B00B19U8FQ]Amazon.com: Customer Reviews: Frontline Tritak 3pk for Large Dogs - 45-88 lbs[/ame]

It does not seem to be isolated but a problem with the product and some dogs.

I recall I used it on Sport for a while but changed as soon as the prescription was over.

Just switched to Trifexis and for some reason thought it was a chewable. The big guy kept spitting it back out so managed to get it down his throat.
That was a few days ago and no adverse reaction.

I use Advantage on my dog and cat. However, when using, I only apply about half the tube and wait quite a while to apply the remainder for this very reason. My dog is a small breed and I'm always very careful re her monthly applications and any required shots. Sometimes, I'll even have shots/vaccines divided over two day period.

Our Yorkie has had similar experiences like many of those mentioned. For him, the flea & tick collars from Preventic ultimately worked (and still work since we live in a heavily wooded area in NJ). Like KathieI's dog, our guy has a very sensitive digestive track as well. We only (and I mean ONLY) feed him Prescription Diet Z/D Canine and Prescription Diet Hypo-Treats. Any variation over the past three years (he is nine) from Preventic or Prescripton Diet has led to problems for him. We still wonder if a dog's weight and age are properly taken into account with anything put on or into it.

I have heard that most dogs don't like it. My wife has an ability to coax the dog to take it..but she very definitely doesn't like it! She has to be bribed with a couple of cookies afterward.

I'm not familiar with Trifexis, but if it's a pill, you can smush it into a little bit of cheese, peanut butter or even a little bit of banana. These are the things we use to giv e our girls their medications. They love all three of them. There is also a product that you can buy to mask the taste. I think it's made by Snausage. We used to use Snausages to give our first dog his meds.

My dogs use Sentinel, an oral flea and heart worm preventative, prescribed for them by their Buffalo Ridge vet. I wrap the pill in a pill pocket. They have no problems eating it and no problems using it.

Thanks for warning us about the new Frontline product.

Our vet switched to Trifexis, which is a heartworm/flea combo. While I'm so happy to get away from a topical, which left two greasy marks for days on our golden, I can't get him to eat the Trifexis out of hand. (He wouldn't eat the last chewable heartworm pill either.) So I smash it up and put it in his breakfast. He has no reaction to it.

But boy, does it ever smell musty. I can't imagine what's in it that makes it smell so bad. No wonder he won't eat it.

We have used Revolution for many years for fleas/heartworm/ticks, etc.
We've used it on dogs ranging in size from 4 lbs to 75 lbs, with no problems ever.
I hate giving my dogs poison every month. Hate it.
But Vets have convinced me that heartworm can be deadly and must be prevented.

I found a flea on my dog, first time ever. Did Frontline, I just hate using that stuff.

Now I'm trying food grade diatomaceous earth. Just sprinkle some on when I brush her, so far so good. Haven't seen a flea in months. I'm planning on treating the yard with it too.

Still using Heartgard, mostly because I'm afraid not to. I do every other month instead of monthly. I read somewhere that from the date of bite it takes three months to cause damage, so I figure every other month should cover it. In NY I took them off it for the winter.

Heartguard used to be all we used. We never had a flea or tick problem when we lived in VA. Once we moved to FL, our girls got infested with both. We tried the collars and finally wound up using Advantage Multi and they haven't had any problems (with fleas and ticks) since. We were told that the fleas and ticks most likely came from the pine needle mulch that is used around the new homes. We have also removed all that and replaced it with stones.

I used regular Frontline on my dogs for years; however, recently the spots where the medication was applied left a large blistering sore. It broke my heart that this was the result of something I did. I went back to the vet and he suggested another medication. I have been using Advantix Plus since that time with no problems.

Bonanza, do you take your dogs to a dog park? I'm wondering where the most likelihood is of picking up fleas. Is a park more likely than just your yard?