How is vaccine efficacy determined?

Closed Thread
Thread Tools
  #31  
Old 11-22-2020, 10:12 AM
collie1228 collie1228 is offline
Gold member
Join Date: Apr 2008
Posts: 1,486
Thanks: 0
Thanked 528 Times in 198 Posts
Default

Quote:
Originally Posted by Buckeye Bleau View Post
What you are describing with the 50% receiving a placebo is a blind study that is used for a different purpose.
In this case they only want to know if it is effective or not and to what percentage it is efficacious.
So they would use known infected individuals and introduce the vaccine or healthy people then give them the pathogen and the vaccine. Right now they say over 90% effective so it resolved the ailment in over 9 of 10 participants.

There were some participants that died after receiving the vaccine, I am not sure where they would fall in the numbers, but then they don’t want to tell you about them.
Of course people died after receiving the vaccine. There were 30,000 people in at least one of the trials, with 15,000 getting the vaccine and 15,000 getting a placebo. In a population of 30,000 people, of all ages, ethnicity, health condition, etc., some people will die. Some will die after drinking milk for breakfast. Did the milk kill them? No. They could have died not necessarily from a vaccine, but just from normal living. Your comment makes it seem like "they" are hiding something. Balderdash. An American corporation could never survive such dishonesty. People who cast dispersion of unfounded suspicion only play into people's fears.
  #32  
Old 11-22-2020, 10:19 AM
biker1 biker1 is offline
Sage
Join Date: May 2014
Posts: 3,126
Thanks: 1
Thanked 932 Times in 524 Posts
Default

That is not what happened with the vaccine trial. They did not start with infected people. They did not introduce the virus to healthy people. There is no "resolving the ailment" because the vaccine is not a therapeutic.

Quote:
Originally Posted by Buckeye Bleau View Post
What you are describing with the 50% receiving a placebo is a blind study that is used for a different purpose.
In this case they only want to know if it is effective or not and to what percentage it is efficacious.
So they would use known infected individuals and introduce the vaccine or healthy people then give them the pathogen and the vaccine. Right now they say over 90% effective so it resolved the ailment in over 9 of 10 participants.

There were some participants that died after receiving the vaccine, I am not sure where they would fall in the numbers, but then they don’t want to tell you about them.
  #33  
Old 11-22-2020, 10:57 AM
merrymini merrymini is offline
Veteran member
Join Date: Oct 2014
Posts: 873
Thanks: 428
Thanked 1,199 Times in 461 Posts
Default

Not me!
  #34  
Old 11-22-2020, 11:18 AM
cassjax2 cassjax2 is offline
Member
Join Date: Dec 2016
Posts: 78
Thanks: 533
Thanked 42 Times in 29 Posts
Default

I just started a Covid vaccine trial this week. We were not given instructions regarding masks, etc. I believe we are expected to use common sense and go about our daily lives. Your line of thought sounds like you think we should be kept away from the public, which I don’t understand. If I had the vaccine (not the placebo) it seems to me that it would be safer to be around me rather than someone who who hasn’t had a vaccination.
  #35  
Old 11-22-2020, 11:20 AM
KRM0614 KRM0614 is offline
Senior Member
Join Date: Jun 2019
Posts: 344
Thanks: 16
Thanked 132 Times in 98 Posts
Default

Quote:
Originally Posted by coffeebean View Post
I have one question as to how the Covid vaccine efficacy is determined. From what I understand, people who participate in the vaccine trials are either vaccinated with the actual vaccine or are vaccinated with a placebo. Then, all of people who participate in the trial go out into the community to "live their lives normally".

Now the question.......are those people in the trial wearing masks and social distancing or are these people in the trials not wearing masks and social distancing? Even if the trial people do NOT follow guidelines, people around them in the community may be following guidelines and wearing masks and social distancing.

I hope you are following my train of thoughts here. Bottom line......just how is the efficacy of a vaccine determined if masking and social distancing are being practiced by those involved in the trial and by the community they are exposed to?
They don’t know ! Just making money off of vaccine without substantial testing ! It’s a joke
  #36  
Old 11-22-2020, 11:22 AM
New Englander New Englander is offline
Platinum member
Join Date: May 2017
Location: Massachusetts, Pinellas, Now Sanibel
Posts: 1,965
Thanks: 618
Thanked 1,252 Times in 424 Posts
Default

Quote:
Originally Posted by Girlcopper View Post
Guess we all just needto wait until the vaccines are approved and more info comes out. Riight now, when a vaccine is approved it will only be available to nursing homes, hospitals etc. Regular people cant have it until around 6 mos after its approved
I'm not a regular person.
  #37  
Old 11-22-2020, 11:33 AM
Byte1 Byte1 is offline
Sage
Join Date: Sep 2017
Location: The Villages, FL
Posts: 2,751
Thanks: 13,974
Thanked 3,644 Times in 1,515 Posts
Default

There have been no reported deaths related to the vaccine trials. Where did that come from?
And who said it was going to be six months before "we" get our vaccinations?
What's with all the "misinformation" being spread as fact?
__________________
Never take life seriously. Nobody gets out alive anyway
  #38  
Old 11-22-2020, 11:39 AM
New Englander New Englander is offline
Platinum member
Join Date: May 2017
Location: Massachusetts, Pinellas, Now Sanibel
Posts: 1,965
Thanks: 618
Thanked 1,252 Times in 424 Posts
Default

Quote:
Originally Posted by dewilson58 View Post
How did you decide in the past??? You probably didn't.
That's true but Covid has changed everything.
  #39  
Old 11-22-2020, 11:58 AM
Altavia Altavia is offline
Sage
Join Date: Jun 2019
Posts: 3,347
Thanks: 1,429
Thanked 2,741 Times in 1,223 Posts
Default

Quote:
Originally Posted by biker1 View Post
Regarding the Pfizer/BioNTech vaccine, the cold storage requirements for shipping and end use are apparently not as extreme as longer term storage. Reference was made to this on a recent press conference at the White House. It appears that Pfizer/BioNTech have shipping containers that use dry ice and the vaccine can be maintained for a week or more with dry ice. Also, once thawed, the vaccine is apparently usable for up to 5 days. Needless to say, the essentially "just in time delivery" nature of this vaccine complicates the logistics but it doesn't sound as if new refrigeration equipment will be needed at every end use location.
It is also likely Pfizer is stability testing in parallel various conditions that may ease the requirements. Launch what they know is stable first.

Moderna has been testing RNA vaccines longer so likely have more long term experience/data.

Last edited by Altavia; 11-22-2020 at 07:51 PM.
  #40  
Old 11-22-2020, 12:02 PM
dewilson58's Avatar
dewilson58 dewilson58 is offline
Sage
Join Date: May 2013
Location: South of 466a, if you don't like me.......I live in Orlando.
Posts: 11,553
Thanks: 847
Thanked 9,753 Times in 3,629 Posts
Default

Quote:
Originally Posted by New Englander View Post
That's true but Covid has changed everything.
Not much has changed..........historically there have been multi-producers. As in the past, this will be a push supply chain rather than a pull supply chain. The needlers will get what they get rather than ordering. The needle'ees don't have enough information (or brain power) to judge which med is better.
__________________
Identifying as Mr. Helpful
  #41  
Old 11-22-2020, 12:16 PM
Two Bills Two Bills is offline
Sage
Join Date: Aug 2016
Posts: 5,672
Thanks: 1,679
Thanked 7,354 Times in 2,508 Posts
Default

Quote:
Originally Posted by Buckeye Bleau View Post
What you are describing with the 50% receiving a placebo is a blind study that is used for a different purpose.
In this case they only want to know if it is effective or not and to what percentage it is efficacious.
So they would use known infected individuals and introduce the vaccine or healthy people then give them the pathogen and the vaccine. Right now they say over 90% effective so it resolved the ailment in over 9 of 10 participants.

There were some participants that died after receiving the vaccine, I am not sure where they would fall in the numbers, but then they don’t want to tell you about them.
Where do people get this stuff from?
  #42  
Old 11-22-2020, 12:30 PM
jhbellew jhbellew is offline
Junior Member
Join Date: Feb 2016
Posts: 1
Thanks: 0
Thanked 0 Times in 0 Posts
Default

We are participating in the Oxford covid trial.
  #43  
Old 11-22-2020, 01:00 PM
Trishakaye Trishakaye is offline
Senior Member
Join Date: Apr 2017
Posts: 104
Thanks: 88
Thanked 87 Times in 42 Posts
Default

If Zeke Emanuel gets his way, those of us 70 and older will be last in line.
  #44  
Old 11-22-2020, 01:08 PM
graciegirl's Avatar
graciegirl graciegirl is offline
Sage
Join Date: Mar 2008
Posts: 40,007
Thanks: 4,853
Thanked 5,506 Times in 1,906 Posts
Send a message via AIM to graciegirl
Default

Quote:
Originally Posted by jhbellew View Post
We are participating in the Oxford covid trial.
I cannot, CANNOT, thank you enough. I think I remember reading this from you before and I think I also recall that you may be retired medical. I am guessing an M.D.

I am so grateful for your gift of high intelligence and the decision to train it further and the courage to go to work every day dealing with many very challenging and impossible situations. Thank you for taking this risk.

No. I see this is your first post. I still thank you so very much.
__________________
It is better to laugh than to cry.
  #45  
Old 11-22-2020, 01:52 PM
Bucco Bucco is offline
Sage
Join Date: Jul 2007
Posts: 7,731
Thanks: 222
Thanked 2,244 Times in 707 Posts
Default

Quote:
Originally Posted by Byte1 View Post
There have been no reported deaths related to the vaccine trials. Where did that come from?
And who said it was going to be six months before "we" get our vaccinations?
What's with all the "misinformation" being spread as fact?
Misinformation spread as facts is frustrating and dangerous, isn't it ?
Closed Thread

Tags
people, distancing, vaccine, trial, social

Thread Tools

You are viewing a new design of the TOTV site. Click here to revert to the old version.

All times are GMT -5. The time now is 07:06 PM.