only one night? please ttry to stay a bit longer.
we stayed at the blue parrot on elizabeth street; convenient and quiet, lovely pool.
do lots of exploring; rent bicycles.
sarabeths for breakfast was great.
ask your hotel hosts for dinner recommendations; the can steer you away from the places that only cater to tourists.
and you must get to mallory square at sunset; there is a lot of unusual entertainment there, including a fascinating feline performance group.
enjoy!