To add to DDoug's suggestion, after running CCleaner on your hard drive and registry, go to the Startup tab in the Tools section of CCleaner. Check to see how many programs are set to load when your computer starts up. Most of them can be disabled without affecting the programs involved. If too many programs are being loaded at startup, it can slow your computer by hogging the RAM and forcing the computer to shift tasks to the hard drive and back, which is much slower.
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