[Villages PL]

Originally Posted by graciegirl

I view this as more user friendly than the extreme diet espoused by the China Study.

Food Pyramids and Plates: What Should You Really Eat? | The Nutrition Source | Harvard T.H. Chan School of Public Health

You just promoted a "user friendly" diet, thereby telling people what they should eat. Welcome to the club.

[CFrance]

Would you like to play Scrabble, VPL?

[dbussone]

Originally Posted by CFrance

Would you like to play Scrabble, VPL?

You will need a three dimensional board for that game.

[Villages PL]

Originally Posted by CFrance

The China Study was first published in the US in January of 2005. And the title of this thread is the China Study. So it is the topic here.

The heading of this thread is, "The China Study: Nutritional effects are the same for all cancers"

So this thread is about the effects of nutrition on cancer and how the risk of cancer and mortality can be reduced.

The topic of nutrition is not the same as genetics.

[CFrance]

Originally Posted by dbussone

You will need a three dimensional board for that game.

Oh. Okay. I thought it might be a lesson in one-dimension.

[Villages PL]

Originally Posted by hulahips

Good book but old. Read it yrs ago

What's your preference now?

[Villages PL]

Originally Posted by dbussone

I have not read the book. I tend to read the scientific studies themselves rather than the articles about them.

As I have said many times, I believe in moderation in all things dietary. If you study the meta-data, they support a moderate physiological approach.

So you support the old "moderation" diet-slogan. If it's a real diet, how would you define it and what supporting evidence do you have?

[Villages PL]

Originally posted by Villages PL; The topic here is about (primary) cancer prevention. I'm not aware of anything in the field of genetics that promises to prevent cancer.

Originally posted by graciegirl; HPV vaccines - Wikipedia, the free encyclopedia

That's not genetic, that's a vaccine.

[graciegirl]

Originally Posted by Villages PL

That's not genetic, that's a vaccine.

Read it again. It would not have been developed without recent genetic research and the unlocking of the human genome..

[Barefoot]

Originally Posted by Villages PL

So you support the old "moderation" diet-slogan. If it's a real diet, how would you define it and what supporting evidence do you have?

Definition of diet: "the kind of food a person habitually eats".
dbussone has said he believes in moderation in all things dietary.
Many people believe in moderation, and live very healthy and happy lives.
And I'm not talking about eating junk food in moderation.


Originally Posted by dbussone
I have not read the book. I tend to read the scientific studies themselves rather than the articles about them.
As I have said many times, I believe in moderation in all things dietary. If you study the meta-data, they support a moderate physiological approach.

[Villages PL]

Originally Posted by graciegirl

Read it again. It would not have been developed without recent genetic research and the unlocking of the human genome..

Nothing in there about genetic research. Anyway, one vaccine does not trump living a healthy lifestyle. A healthy lifestyle doesn't include promiscuity.

[dbussone]

Originally Posted by graciegirl

Read it again. It would not have been developed without recent genetic research and the unlocking of the human genome..

Gracie - you are correct as usual. I am including some of the genetic work done on HPV prior to the development of the vaccine. I have included the abstract and conclusions. Please read the last sentence of the conclusions. A link to the paper is found at the end of this post.

Public Health Genomics
Karger Publishers
Human Papillomaviruses: Genetic Basis of Carcinogenicity
Robert D. Burk, Zigui Chen, and Koenraad Van Doorslaer

Additional article information

Abstract
Persistent infection by specific oncogenic human papillomaviruses (HPVs) is established as the necessary cause of cervix cancer. DNA sequence differences between HPV genomes determine whether an HPV has the potential to cause cancer. Of the more than 100 HPV genotypes characterized at the genetic level, at least 15 are associated, to varying degrees, with cervical cancer. Classification based on nucleotide similarity places nearly all HPVs that infect the cervicovaginal area within the α-PV genus. Within this genus, phylogenetic trees inferred from the entire viral genome cluster all cancer-causing types together, suggesting the existence of a common ancestor for the oncogenic HPVs. However, in separate trees built from the early open reading frames (ORFs; i.e. E1, E2, E6, E7) or the late ORFs (i.e. L1, L2), the carcinogenic potential sorts with the early region of the genome, but not the late region. Thus, genetic differences within the early region specify the pathogenic potential of α-HPV infections. Since the HPV genomes are monophyletic and sites are highly correlated across the genome, diagnosis of oncogenic types and non-oncogenic types can be accomplished using any region across the genome. Here we review our current understanding of the evolutionary history of the oncogenic HPVs, in particular, we focus on the importance of viral genome heterogeneity and discuss the genetic basis for the oncogenic phenotype in some but not all α-PVs.

Key Words: Human papillomavirus, Cervix cancer, Evolution, Phylogeny
Evolution of the Association between Human Papillomavirus and Cervix Cancer
Although an infectious cause of genital warts was suspected in ancient times, interest in ‘wart virus’ research was only galvanized by the suggestion that human papillomavirus (HPV) was the long-sought sexually transmitted etiological agent of cervical cancer. In 2009, Prof. Harold zur Hausen was awarded the Nobel Prize for this innovative idea [1] and demonstrating HPV genomes in cervical cancer tissues [2, 3]. Confluence of idea and technology was enabled by recombinant DNA methods, the cloning of HPV genomes [4] and the use of molecular hybridization. This quantum advance was critical, since standard virologic methods such as serology were not readily available for HPV molecular epidemiological investigations. The free and widespread distribution of cloned HPV genomes by the Heidelberg group and the commencement of an annual international papillomavirus conference accelerated discovery and fostered a collaborative culture within the PV scientific community. Breakthroughs in understanding the molecular pathogenesis have and continue to revolutionize the screening, diagnosis, treatment and prevention of HPV-associated diseases. From a public health viewpoint, HPV has become the model for molecular medicine and how technology can be readily applied to global health problems.



Conclusion and Perspectives
HPVs are a major cause of morbidity and mortality. Characterization and classification of the large group of HPV types contributing to disease has provided important molecular tools for the medical community, resulting in novel diagnostic, screening and prevention strategies. Current studies demonstrate a viral genetic basis of pathogenicity derived from evolution of a common ancestor of all oncogenic HPV types. Nevertheless, understanding the exact genetic basis of HPV oncogenicity is highly complex and will require innovative analytic methods. Study of α-HPV genomics can serve as a model for non-recombinant genome evolution, genetic determinants of pathogenicity and application of genomics for therapeutics.


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835381/

[Villages PL]

Originally Posted by Barefoot

Definition of diet: "the kind of food a person habitually eats".
dbussone has said he believes in moderation in all things dietary.
Many people believe in moderation, and live very healthy and happy lives.
And I'm not talking about eating junk food in moderation.


Originally Posted by dbussone
I have not read the book. I tend to read the scientific studies themselves rather than the articles about them.
As I have said many times, I believe in moderation in all things dietary. If you study the meta-data, they support a moderate physiological approach.

Evidently, the person I asked my questions of couldn't answer them so you jumped in, but your answer is unsatisfactory and incomplete.

[dbussone]

Originally Posted by Villages PL

Evidently, the person I asked my questions of couldn't answer them so you jumped in, but your answer is unsatisfactory and incomplete.

I did answer it. I said I didn't read the book. I'm sorry if you find that response unsatisfactory - it is a response. That you find it unsatisfactory and incomplete is not my problem.

[Villages PL]

Originally Posted by graciegirl

Read it again. It would not have been developed without recent genetic research and the unlocking of the human genome..

Gracie, you were wrong as usual. The link you provided contained nothing about genetics.