[Taltarzac725]

Is it a Dire Wolf? Or something else entirely?


Just a moment...


I do not think you can go home again in that sense of the word. Too much has changed. This also applies to the Dire Wolf.

[mbene]

Entertaining video about the not dire wolves.

https://youtu.be/wWs55JOS-fg?si=1KEJZworrQ9PSX6o

[fdpaq0580]

Looks do not make a Dire Wolf. Only 100% Dire Wolf DNA counts. Identifying as a Dire Wolf doesn't work ... and I won't make that mistake again. Doc says I should be mostly healed in a couple of weeks.
Time for my antibiotics, again.

[asianthree]

So DNA from skeletal remains then extracted DNA using Grey wolf (closest DNA to Dire in modern times) create embryos.

Was the actual Dire DNA extracted from more than one Dire using each to create an embryo or hopeful at least 2 different DNA specimens were used.

Once the pups were born DNA testing against the original Dire, and the Hybrid Dire would be continuously studied, using different specimens, if available. Then take pup with the highest percentage of Dire create new embryos from original Dire. Possibly creating a higher DNA of Dire Wolf.

The company isn’t looking for “it just looks like a Dire” because funding could go away.
The hope is with each specimen the DNA % will successfully increase using Lab Created Embryo from Hybrid pup again using DNA of extinct Dire.

Then again is the Dire DNA uncompromised? Or other species involved previously with the Dire that skeletal remains have not been discovered? As of now it’s not actually a Dire Wolf but a Dog with a handful of Dire Wolf genes spliced in.

The question is the purpose of experiment. Their habitat is long gone

[Taltarzac725]

Originally Posted by asianthree

So DNA from skeletal remains then extracted DNA using Grey wolf (closest DNA to Dire in modern times) create embryos.

Was the actual Dire DNA extracted from more than one Dire using each to create an embryo or hopeful at least 2 different DNA specimens were used.

Once the pups were born DNA testing against the original Dire, and the Hybrid Dire would be continuously studied, using different specimens, if available. Then take pup with the highest percentage of Dire create new embryos from original Dire. Possibly creating a higher DNA of Dire Wolf.

The company isn’t looking for “it just looks like a Dire” because funding could go away.
The hope is with each specimen the DNA % will successfully increase using Lab Created Embryo from Hybrid pup again using DNA of extinct Dire.

Then again is the Dire DNA uncompromised? Or other species involved previously with the Dire that skeletal remains have not been discovered? As of now it’s not actually a Dire Wolf but a Dog with a handful of Dire Wolf genes spliced in.

The question is the purpose of experiment. Their habitat is long gone

I suppose the worry is that they will go Jurassic Park on their handlers.

[Taltarzac725]

It will be interesting to see how big these three pups get.

[fdpaq0580]

Originally Posted by Taltarzac725

It will be interesting to see how big these three pups get.

🤫🤫 shhh. Not so loud or everyone will want one.

[fdpaq0580]

Originally Posted by asianthree

So DNA from skeletal remains then extracted DNA using Grey wolf (closest DNA to Dire in modern times) create embryos.

Was the actual Dire DNA extracted from more than one Dire using each to create an embryo or hopeful at least 2 different DNA specimens were used.

Once the pups were born DNA testing against the original Dire, and the Hybrid Dire would be continuously studied, using different specimens, if available. Then take pup with the highest percentage of Dire create new embryos from original Dire. Possibly creating a higher DNA of Dire Wolf.

The company isn’t looking for “it just looks like a Dire” because funding could go away.
The hope is with each specimen the DNA % will successfully increase using Lab Created Embryo from Hybrid pup again using DNA of extinct Dire.

Then again is the Dire DNA uncompromised? Or other species involved previously with the Dire that skeletal remains have not been discovered? As of now it’s not actually a Dire Wolf but a Dog with a handful of Dire Wolf genes spliced in.

The question is the purpose of experiment. Their habitat is long gone

Frustrated "model" builders. Habitat be damned. It will look nice over the fireplace.

[airstreamingypsy]

We are a few months away from DireDoodles.

[Taltarzac725]

Originally Posted by airstreamingypsy

We are a few months away from DireDoodles.

Love it.

[jimjamuser]

Originally Posted by Taltarzac725

Is it a Dire Wolf? Or something else entirely?


Just a moment...


I do not think you can go home again in that sense of the word. Too much has changed. This also applies to the Dire Wolf.

My wife took one look at those young Dire Wolf puppies and said, "So cute, the puppies are simply DIRLING"!

[fdpaq0580]

Say you found an antique car part. A really cool hood ornament from a currently non-existant Diremobile. You found a list of parts and pictures. You borrow (splice in) parts of various other cars, new and old. You even manufacture parts that no longer exist because the metal, and other materials were inferior to the modern replacement materials. You cobble all the parts from various sources, like a demented Dr Frankenmechanic, start it up, attach the hood ornament. Have you really "resurrected" an authentic Diremobile? Or just a replica.

The successful combining of a viable Direwolf egg and sperms will produce a Direwolf pup. Splicing genes with a few Direwolf genes, like Dr Frankenstein splicing various body parts to produce a person. At least the good doctor used all parts of the same species.

NO such thing (yet) as de-extinction. What do you think?

[asianthree]

Originally Posted by fdpaq0580

The successful combining of a viable Direwolf egg and sperms will produce a Direwolf pup. Splicing genes with a few Direwolf genes, like Dr Frankenstein splicing various body parts to produce a person. At least the good doctor used all parts of the same species.

NO such thing (yet) as de-extinction. What do you think?

DNA spliced with a grey wolf. At this time no evidence has been presented as to the percentage of Dire to Gray Wolf with the embryos implanted in a dog of unspecified description. No identification of what DNA samples are being used. I doubt researchers will present findings for the first birth, of the 3 pups.
Or if there are plans to take the pups with the larger % of Dire splice with another Dire DNA.
Then again are the DNA samples pure Dire? Without extensive DNA studies of each remains available, those results are a questionable. Is there a reason for research to hybrid a Dire, NO, but the grant needs to be spent on something

DNA of a skeletal specimen can be traced as far back as 4000BC. There are thousands of remains in unmarked drawers at the Smithsonian.

For many years the goal is to not only identify the remains, by age, sex, and ethnicity, link those results to living Tribesmen and return to sacred ground.

[daniel200]

According to a Science Friday podcast, the dire wolf DNA is 99.5% the same as a gray wolf. That means about 5 million DNA base pairs are different. The scientist used CRISPR technology to insert 14 DNA base pairs that were removed from viable dire wolf DNA.

So these pups still have about 5 million DNA differences (just 14 less than before)

[fdpaq0580]

Originally Posted by daniel200

According to a Science Friday podcast, the dire wolf DNA is 99.5% the same as a gray wolf. That means about 5 million DNA base pairs are different. The scientist used CRISPR technology to insert 14 DNA base pairs that were removed from viable dire wolf DNA.

So these pups still have about 5 million DNA differences (just 14 less than before)

So, kinda like a gray wolf whose great to the 10th power, parent cross bred with a dire wolf, thousands of years ago. So, am I, or you, Homosapian, or Neanderthal, or Cro-magnon?