Early peek at Remdesivir data shows promise against Covid 19

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Old 04-18-2020, 07:05 AM
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Originally Posted by vermonster View Post
And in Sumter County about 10%, the highest rate of any county in Florida.
Can you link us to those statistics? I was just thinking the opposite. I have been closely following the deaths in Sumter, Lake and Marion counties and Lake is higher than us, but the highest death toll are in the two counties around Miami. Thank you to Blueash for pointing out it was RATE...percentage discussed here.

Also someone on this thread said that the seasonal flu shot was not a vaccine. That is incorrect; Key Facts About Seasonal Flu Vaccine | CDC

Also someone said that they don't appreciate the posts from the M.D.s who live here. I certainly do and I know that many do as well.

There is a lot of misinformation circling about. A lot of it is simply because we have not had enough time and statistics to really evaluate the hard data that changes every day. The world has only been following this completely new and dangerous virus since late November when the outbreak and deaths were first reported in Wuhan in China.
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Last edited by graciegirl; 04-18-2020 at 09:31 AM.
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Old 04-18-2020, 07:06 AM
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Originally Posted by theruizs View Post
Why do people keep saying this? The infection rate of this virus is something like three times that of the flu. So if no measures are taken it could easily eclipse the flu infection rate. Also, the death rate of those infected from flu is a fraction of a percent, but from this virus it is 2.76% here in Florida, 4.60% in the US, and 6.83% worldwide (46 times the flu death rate minimum). If no measures are taking this would make flu look like a hiccup. Also, the rate of hospitalization from this virus is far higher than the flu, so it is a huge strain on our health care system. If no measures are taken at all it would be overwhelmed. This is not like the flu!.
There's no way you could possibly know that because no one knows how many people have gotten it. No one knows, including the experts. Remember they were telling is 2 miilion could die, now it's 60,000. Remember you don't need masks, now they're suggested or required? You read everything and make up your own mind.
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Old 04-18-2020, 07:27 AM
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Good advice.
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Old 04-18-2020, 07:31 AM
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when you're trying to solve a complex challenge you don't take anything off the table until it is proven to not be a viable approach, or a viable solution has been found and is being successfully implemented

Thankfully our leaders stepped up and are leading.... no leader in history has ever made everyone happy 100% of the time
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Old 04-18-2020, 07:44 AM
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Originally Posted by vermonster View Post
And in Sumter County about 10%, the highest rate of any county in Florida.
Without any knowledge of how many had the virus, there is no way to calculate the death toll percentage. We have insufficient testing capability to even make a swag about the death rate.
  #21  
Old 04-18-2020, 07:53 AM
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Originally Posted by MOMOH View Post
FROM MY FRIEND THE DOCTOR:

Is remdesivir the COVID miracle we've been waiting for?
Gilead certainly hopes you think it is

Gregory Katz
Apr 17


The medical world was buzzing...
Wow. Logical, professional, informative & non-political... WHAT'S WRONG WITH YOU?!?!?!
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Old 04-18-2020, 08:17 AM
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Quote:
Originally Posted by vermonster
And in Sumter County about 10%, the highest rate of any county in Florida.
Quote:
Originally Posted by kanoa1kale2 View Post
Without any knowledge of how many had the virus, there is no way to calculate the death toll percentage. We have insufficient testing capability to even make a swag about the death rate.
Let's start with that one. Death rate for COVID is calculated using deaths divided by cases, times 100. This is true in every county and every country. Obviously lack of broad testing despite its promised universal availability does artificially inflate the calculation. But the same problem is everywhere. Vermonster is correct. Sumter also has the highest average age of COVID patients. I think these two data points are related.

CASE DATA FOR SUMTER as of 9 AM 4/18
Total Cases: 120 [these are test positive cases]
Deaths: 11 11/120 = .092 times 100 = 9.2%
Demographics of Cases
Age: Age Range: 18 to 92
Median Age: 68
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Last edited by blueash; 04-18-2020 at 08:30 AM.
  #23  
Old 04-18-2020, 08:19 AM
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Originally posted by devorejh
Unproven treatments? They may be unproven to our FDA but that’s no surprise. The drugs that the president has touted are being used all over the rest of the world and have had clinical trials. Why is it the United States feels we have to reinvent the wheel. I will say the FDA has been fairly responsible and allowing these treatments since they are working in many other countries
Remdesivir, the drug being discussed in this thread, was indeed touted by Trump. But, completely contrary to your posting, Remdesivir has never been used all over the world. It has not even been commercially manufactured. It is an experimental drug that has never left the testing phase. It has not had adequate successful clinical trials yet for any condition which is why it is not being marketed anywhere for anything. The FDA is not behind the rest of the world as this drug is unproven worldwide. This trial and others are attempting to find a clinical use for a product with in vitro and theoretical reasons to hope will work.

Please look things up before you post. Certainty is not the same as accuracy.
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Old 04-18-2020, 08:24 AM
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Originally posted by devorejh
What you get for the flu is a flu shot, it is not a vaccine. Don’t understand why people do not know the difference. A vaccine is something you take one time and you’re done, like smallpox or polio
When you suggest people do not know the difference, it would be best if you knew the difference. Gracie provided you a link. It is especially enlightening that you picked those two diseases. Polio requires 4 doses, not one, to complete the primary and booster series. Smallpox is no longer given.
The word vaccine does however relate to the history of smallpox. Edward Jenner noticed that milkmaids who contracted cowpox seemed resistant to getting smallpox. He theorized that the milder cowpox illness was protective. He tested taking fluid from cowpox blisters and inoculating people with that fluid. In Latin cow is "vacca" The word vaccine is now used medically and commonly for all the shots and oral products used.
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Old 04-18-2020, 08:28 AM
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Originally Posted by hollywoodz View Post
Having been in the medical-legal field for nearly five decades, my suggestion is to ONLY follow the words of expert physicians and scientists, and NOT those not so qualified or experienced in advancing your health with scientifically unproven or untested pharmaceuticals. This includes the words that come from politicians that have no such qualifications either!
LOL I included that excerpt from the article only to show that POTUS has spoken about other drugs besides hydroxychloroquine.

Maybe he should say that there are no drugs that offer hope and we're all gonna die?

Last edited by GoodLife; 04-18-2020 at 09:34 AM.
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Old 04-18-2020, 09:20 AM
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Originally Posted by theruizs View Post
Why do people keep saying this? The infection rate of this virus is something like three times that of the flu. So if no measures are taken it could easily eclipse the flu infection rate. Also, the death rate of those infected from flu is a fraction of a percent, but from this virus it is 2.76% here in Florida, 4.60% in the US, and 6.83% worldwide (46 times the flu death rate minimum). If no measures are taking this would make flu look like a hiccup. Also, the rate of hospitalization from this virus is far higher than the flu, so it is a huge strain on our health care system. If no measures are taken at all it would be overwhelmed. This is not like the flu!.
Simply not true: “ A group of researchers analyzed data from China and found that the overall mortality rate of COVID-19 was 1.38%. But if they adjusted for cases that likely went unaccounted for due to their mild or asymptomatic nature, the overall mortality rate decreased to around 0.66%, they reported on March 30 in journal The Lancet Infectious Diseases.”
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Old 04-18-2020, 11:05 AM
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Prof Simon Maxwell, Professor of Clinical Pharmacology and Prescribing, University of Edinburgh, said:

“The research is interesting but doesn’t prove anything at this point: the data are from a small and uncontrolled study. Remdesivir is currently being assessed in large scale clinical studies, which will be critical in determining whether it is a safe and effective treatment for COVID-19. This is not least because there were some adverse events (60%) reported in the current study, some of them serious (23%), including multiple organ failure, septic shock, acute kidney injury, and hypotension.”
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Old 04-18-2020, 12:01 PM
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Originally Posted by jklfairwin View Post
Prof Simon Maxwell, Professor of Clinical Pharmacology and Prescribing, University of Edinburgh, said:

“The research is interesting but doesn’t prove anything at this point: the data are from a small and uncontrolled study. Remdesivir is currently being assessed in large scale clinical studies, which will be critical in determining whether it is a safe and effective treatment for COVID-19. This is not least because there were some adverse events (60%) reported in the current study, some of them serious (23%), including multiple organ failure, septic shock, acute kidney injury, and hypotension.”
Yes we know this because we read the study I linked, just like Prof Simon Maxwell.
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Old 04-18-2020, 12:28 PM
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Originally Posted by GoodLife View Post
LOL I included that excerpt from the article only to show that POTUS has spoken about other drugs besides hydroxychloroquine.

Maybe he should say that there are no drugs that offer hope and we're all gonna die?
Maybe he should let the physicians who actually understand the material do the commenting on medications. He can and should offer hope and include statements like "I understand that there are trials of many treatments ongoing here and elsewhere in the world. I'll let Dr. Fauci answer any questions about details of those trials." Instead when a question about medicine was directed at Dr. Fauci he interrupted him and ordered him not to answer.
  #30  
Old 04-18-2020, 01:46 PM
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Originally Posted by blueash View Post
Maybe he should let the physicians who actually understand the material do the commenting on medications. He can and should offer hope and include statements like "I understand that there are trials of many treatments ongoing here and elsewhere in the world. I'll let Dr. Fauci answer any questions about details of those trials." Instead when a question about medicine was directed at Dr. Fauci he interrupted him and ordered him not to answer.
He was just relaying info from PHYSICIANS who were and are reporting results from various drugs. POTUS has never said take this drug you'll be cured. Just measured statements like "It may or may not work" "I am not a Doctor" "I may take it, I'll have to ask my Doctors"

Besides, DR Fauci is not infallible and has made several blunderous statements.

“it’s a very, very low risk to the United States. … It isn’t something the American public needs to worry about or be frightened about. Because we have ways of preparing and screening of people coming in [from China] "

“in all the history of respiratory viruses, asymptomatic transmission has never been the driver of outbreaks. An epidemic is not driven by asymptomatic carriers.”
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