New study on Hydroxychloroquine with Azithromycin, failure

» Site Navigation
Home Page The Villages Maps The Villages Activities The Villages Clubs The Villages Book Healthcare Rentals Real Estate Section Classified Section The Villages Directory Home Improvement Site Guidelines Advertising Info Register Now Video Tutorials Frequently Asked Questions
» Newsletter Signup
» Premium Tower
» Advertisements
» Trending News
» Tower Sponsors




















» Premium Sponsors
» Banner Sponsors
» Advertisements
Closed Thread
Thread Tools
  #16  
Old 04-03-2020, 07:01 AM
karostay's Avatar
karostay karostay is offline
Sage
Join Date: Sep 2011
Location: Conn/Maine /
Posts: 2,710
Thanks: 110
Thanked 1,281 Times in 489 Posts
Default

new class of Drs that graduated from online U
__________________
Don't take life Too Serious ..It isn't permanent
  #17  
Old 04-03-2020, 08:09 AM
blueash's Avatar
blueash blueash is offline
Sage
Join Date: Jan 2008
Posts: 2,612
Thanks: 163
Thanked 1,833 Times in 461 Posts
Default

Quote:
Originally Posted by OrangeBlossomBaby View Post
11 patients makes for an absolutely guaranteed, solid, confirmed, bonafide, verified, reliable prediction that this cocktail will -not- work 100%, AND that it comes with risk of death (since 1 had to discontinue because the drug was giving him deadly side effect).

When you start with the hypothesis that it's 100% effective, then a single failure to be effective - crumbles that hypothesis and renders it categorically false.
Be cautious not to over-interpret findings in either direction. The original study from Marseille did report that 100% of six patients given both hydroxychloroquine and Zithromax cleared of detectible virus, both by culture and PCR. However the author made no claim that it would work 100% on all patients. Most studies report a confidence interval or range. That is - given the result we found, what is the true result in a larger study likely to show. These authors did not calculate an interval. They just reported their data.

Think of it this way. You are going to flip a coin. We know that it should be 1/2 heads, 1/2 tails. But you are coin naïve and don't know that. So you flip it six times and get all heads. Does that prove that all coins have heads on both sides? Or that no matter what else, the head side always lands up even if there are other options? Another group tries to replicate. It tosses a coin 10 times. It gets 8 tails and 2 heads. That doesn't prove your 6 results were wrong only that your study had too few examples to establish the scientific proof to answer "What are the odds when you flip a coin". The only thing the second study did is show that any conclusion made on the first 6 coin flips was wrong as the test size was inadequate.

When you hear about meta analysis studies, those are when the work of other groups is combined to get a better picture because we have more numbers. In our coin case we can say we have 6 + 10 = 16 flips if we combine data. And our result is amazingly 8 heads and 8 tails. It doesn't usually work out that well. But even with that result it is way to early to say "coin flips will result in 1/2 heads" because clearly if the real result is 60% to 40% after only 16 flips we could easily have 1/2, 1/2. If this were a study we should report our result as 50% heads with a confidence interval.

This is a long explanation but it is important to understand why some are cautious about drawing final conclusions from small data sets. However, your statement that the second study established that use of HCZ and Zith is NOT 100% effective is accurate. It still could be 99% and give the results we have so far. It could be 0 % and give the results we have so far. How could it be 0 when there are patients who got the meds and cleared. It surely must be higher than zero!

No, because you cannot show that those patients who cleared did so because of the drug. That is why you need a control group as I have stressed. You have to show how many patients become test negative with no treatment before you can establish your intervention had an effect on the outcome

Example: If without any treatment 1/2 of Covid patients become test negative by 5 days [their body clears the virus itself] and 1/2 are still positive by 5 days then I do foot massage on 10 patients with Covid and publish my result that after only 5 days of massage 1/2 of those patients are now Covid free, my data is true but any conclusion such as Foot Massage has been shown to cure 50% of patients is false. Foot massage caused no improvement at all.

It is very difficult for people not to conclude that results must be caused by prior actions. The phrase post hoc ergo propter hoc gets thrown about in that situation. My favorite example is that you can show that having the sun warm the water at the beach causes drowning. The data are clear. As the water gets warmer more people drown. You see through that because you know there is some other factor I am not taking into consideration. But that is not clear if you don't already have knowledge about the topic and can't see the hocus pocus of the statistical manipulation.
__________________
Men plug the dikes of their most needed beliefs with whatever mud they can find. - Clifford Geertz
  #18  
Old 04-03-2020, 08:54 AM
blueash's Avatar
blueash blueash is offline
Sage
Join Date: Jan 2008
Posts: 2,612
Thanks: 163
Thanked 1,833 Times in 461 Posts
Default

I have for you a more comprehensive poll result on the proper handling of Covid

Just a brief update on the current situation in America ......... American Medical Association has weighed in on Trump's COVID response:

The Allergists were in favor of scratching it, but the Dermatologists advised not to make any rash moves.
The Gastroenterologists had sort of a gut feeling about it, but the Neurologists thought the Administration had a lot of nerve.
Meanwhile, Obstetricians felt certain everyone was laboring under a misconception, while the Ophthalmologists considered the idea shortsighted.
Pathologists yelled, "Over my dead body!" while the Pediatricians said, "Oh, grow up!"
The Psychiatrists thought the whole idea was madness, while the Radiologists could see right through it.
Surgeons decided to wash their hands of the whole thing and the Internists claimed it would indeed be a bitter pill to swallow.
The Plastic Surgeons opined that this proposal would "put a whole new face on the matter."
The Podiatrists thought it was a step forward, but the Urologists were ****ed off at the whole idea.
Anesthesiologists thought the whole idea was a gas, and those lofty Cardiologists didn't have the heart to say no.
In the end, the Proctologists won out, leaving the entire decision up to the ******** in Washington.
__________________
Men plug the dikes of their most needed beliefs with whatever mud they can find. - Clifford Geertz
  #19  
Old 04-03-2020, 09:14 AM
graciegirl's Avatar
graciegirl graciegirl is offline
Sage
Join Date: Mar 2008
Posts: 39,435
Thanks: 4,204
Thanked 4,713 Times in 1,608 Posts
Send a message via AIM to graciegirl
Default

Quote:
Originally Posted by blueash View Post
I have for you a more comprehensive poll result on the proper handling of Covid

Just a brief update on the current situation in America ......... American Medical Association has weighed in on Trump's COVID response:

The Allergists were in favor of scratching it, but the Dermatologists advised not to make any rash moves.
The Gastroenterologists had sort of a gut feeling about it, but the Neurologists thought the Administration had a lot of nerve.
Meanwhile, Obstetricians felt certain everyone was laboring under a misconception, while the Ophthalmologists considered the idea shortsighted.
Pathologists yelled, "Over my dead body!" while the Pediatricians said, "Oh, grow up!"
The Psychiatrists thought the whole idea was madness, while the Radiologists could see right through it.
Surgeons decided to wash their hands of the whole thing and the Internists claimed it would indeed be a bitter pill to swallow.
The Plastic Surgeons opined that this proposal would "put a whole new face on the matter."
The Podiatrists thought it was a step forward, but the Urologists were ****ed off at the whole idea.
Anesthesiologists thought the whole idea was a gas, and those lofty Cardiologists didn't have the heart to say no.
In the end, the Proctologists won out, leaving the entire decision up to the ******** in Washington.
And the psychologists knew how they felt about it.
__________________
It is better to laugh than to cry.
  #20  
Old 04-03-2020, 11:46 PM
chet2020 chet2020 is offline
Senior Member
Join Date: Mar 2020
Posts: 173
Thanks: 111
Thanked 181 Times in 83 Posts
Default

Gov Cuomo mentioned a hydroxychloroquine treatment study at one of his press conferences. I keep looking for it on clinicaltrials.gov, but am not finding it. What I have found:

Sanofi: Hydroxychloroquine in Outpatient Adults With COVID-19 (210 patients). This tests drop in viral load in patients diagnosed with coronavirus per PCR test.

Columbia U: Hydroxychloroquine Post Exposure Prophylaxis for Coronavirus Disease (COVID-19). This study will test if hydroxychloroquine may be used to prevent the development of COVID-19 symptoms in persons who live with an individual who has been diagnosed with COVID-19.

There are other studies also, but I'm looking for a treatment study of hospitalized (seriously ill) patients with COVID-19 being run in NY. Maybe it's posted and I'm missing it. The Sanofi study is listed as "recruiting" and was just posted today, so perhaps the study I'm looking for simply has not dropped yet. Or maybe I am misinterpreting Cuomo's remarks. If anyone has any insights, I'm interested. Thank you.
  #21  
Old 04-04-2020, 04:39 AM
Challenger's Avatar
Challenger Challenger is offline
Soaring Eagle member
Join Date: May 2010
Posts: 2,189
Thanks: 48
Thanked 314 Times in 133 Posts
Default

Quote:
Originally Posted by blueash View Post
Sure enough. Mrs Blueash asks what I'm doing on the laptop. I just tell her "pie fights"
" and ye shall know the Truth, and the Truth shall make you free"
__________________
"All that is necessary for the triumph of evil is that good men do nothing" Edmund Burke 1729-1797
Closed Thread

Tags
patients, hydroxychloroquine, days, treatment, azithromycin

Thread Tools

You are viewing a new design of the TOTV site. Click here to revert to the old version.

All times are GMT -5. The time now is 08:06 AM.