We may reach herd immunity sooner than you think We may reach herd immunity sooner than you think - Talk of The Villages Florida

We may reach herd immunity sooner than you think

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Old 07-02-2020, 06:16 PM
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Default We may reach herd immunity sooner than you think

Some new studies give some signs for hope that this pandemic may run out of steam sooner than we think. But first a couple of graphs.

Sweden vs USA, deaths per million (Sweden = Black USA = Red)​

us-vs-sweden-deaths-jpg

Sweden vs USA cases per million​

us-vs-sweden-cases-png

Both deaths and cases per million look very similar when graphed. Sweden did not lock down economy, close schools, use masks while most of the USA did. Sweden did advise citizens to social distance, but nothing like the shelter at home guidelines issued in USA. Sweden's death rate per million is slightly higher than USA, but the graphs show a very similar rise to a peak and then fall. Cases per day rose quickly in both countries, then flatten and both showing a recent rise. But deaths are falling in both countries, not following the recent rise in cases. (The blip you see in Sweden recent deaths was caused by them adding some covid probable deaths in late June) ​

The reason deaths do not seem to be rising is probably the same for both countries, the new cases being found are mostly younger and asymptomatic, not tested before and in an age group that does not die from the virus frequently.​

Anyway, the graphs and data show something is at work here and it doesn't have much to do with lockdowns etc.​

Now lets look at Florida vs New York.​

Florida vs New York daily deaths (NY = Red FL = Green)​

ny-vs-fl-deaths-jpg

Boy we sure did flatten that curve huh? Good job Florida!​

Florida vs New York daily new cases​

ny-vs-fl-cases-jpg

Wait a minute! Why are new cases in NY going down while ours are going up? NY opened up a month ago, they had huge Floyd protests there too. Maybe they are just better at reopening than we are, or maybe their protesters and a huge percentage of New Yorkers are immune.​

Recently CDC Director Redfield said this: "Our best estimate right now is that for every case that's reported, there actually are 10 other infections," Dr. Robert Redfield, director of the CDC, said on a call with reporters Thursday.​

OK, so NYC has had 212,000 confirmed cases times 10 = 2,120,000 actual cases if CDC correct. Population of NYC is 8 million or so, so that's about 25% of the population that are immune.​

Several new studies have found another kind of immunity from the virus different from antibodies. New research from Karolinska Institutet and Karolinska University Hospital shows that many people with mild or asymptomatic COVID-19 demonstrate so-called T-cell-mediated immunity to the new coronavirus, even if they have not tested positively for antibodies. According to the researchers, this means that public immunity is probably higher than antibody tests suggest. Our results indicate that roughly twice as many people have developed T-cell immunity compared with those who we can detect antibodies in.”

So some people have such strong T cells that they fight off the virus without producing antibodies. Could be from exposure to other coronaviruses like the common cold. This study estimates there are twice as many T cell immune individuals as there are that have antibodies.

So now you can estimate that over 4 million New York City people would either have antibodies or T cell immunity. That's 50% of the population. Is that enough for herd immunity? It sure looks like it in their graph showing new case numbers dwindling down pretty rapidly.

A team at Stanford lead by Nobel Laureate Michael Levitt have been studying data from countries all over the world and think the virus begins to burn out and run out of hosts when infected individuals + asymptomatics reach a certain threshold. Levitt and colleagues think that the existence of large numbers of invisible cases of individuals who are asymptomatic and are not counted as confirmed cases may explain the non exponential behavior of the pandemic, the known cases can't find new people to infect because the invisible cases have already done so.

Basically, Levitt is saying that the various regions his team are tracking are reaching herd immunity faster and at lower levels than many epidemiologists think likely (60-70%)

"I personally think it's less than 30%" said Levitt.

A recent model by MIT predicts that absent a vaccine, the pandemic will grind on until next spring and that Global cases will rise to 249 million with deaths rising to 1.75 million in the 84 countries they survey.

I hope the Stanford guy is right. New York City data looks like he may be.
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Old 07-02-2020, 09:10 PM
themartianchick themartianchick is offline
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Default Or maybe not!

The problem with this is that there is no reason to believe that herd immunity to COVID-19 can be achieved, at all. Some people have recovered and become infected again. I love data and statistics but a state like NY has had two very distinct experiences with the virus (upstate vs. downstate) and sometimes the data is skewed when viewed at a macro-level, rather than at a micro-level.

NY City is a high-density area that was hit with the virus fairly early on and didn't have as much time to ramp up. Few aspects of life in NYC are private: transportation, shopping, apartment living, etc...Most rely on public systems where everyone is breathing the exhaled air of someone else. There also wasn't a lot known about the characteristics of the virus when NYC was hit. NYC absolutely had to shut down when it did in order to stem the tide. For the purposes of comparison, we should probably compare the data from Miami and NYC. However, those cities are in very different phases of the virus. NYC does not seem to be in an upswing, but Miami seems to be.

I live in a city in Central NY State. Our experience with COVID-19 was entirely different from that of NYC, but we certainly didn't get through it unscathed. We wear our masks (for the most part ) and practice social distancing but we still get hotspots when people decide that the mask mandate doesn't apply to them or decide that it is too onerous to comply for one reason or another. We seem to see our greatest outbreaks in manufacturing and warehousing facilities.

My concern with Florida is the sheer number of seniors and people with underlying health conditions juxtaposed against the numbers of people who refuse to wear a mask and/or practice social distancing. Right now, Florida is on the upswing and we don't know how high it will swing nor how many it will take out. The good news is that we have learned things about the virus as it has raged through other nations, states and communities. This has led to slightly better outcomes for patients battling COVID-19 in places like Florida and Texas.

In Florida, the problem with herd immunity (if it's even achievable) is that far too many of the herd are older and in failing health. To achieve it, we will likely lose a large portion of that subset within our herd.
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Old 07-02-2020, 10:16 PM
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Great info. Thanks for posting!
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Old 07-03-2020, 06:51 AM
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Originally Posted by themartianchick View Post
The problem with this is that there is no reason to believe that herd immunity to COVID-19 can be achieved, at all. Some people have recovered and become infected again. I love data and statistics but a state like NY has had two very distinct experiences with the virus (upstate vs. downstate) and sometimes the data is skewed when viewed at a macro-level, rather than at a micro-level.

NY City is a high-density area that was hit with the virus fairly early on and didn't have as much time to ramp up. Few aspects of life in NYC are private: transportation, shopping, apartment living, etc...Most rely on public systems where everyone is breathing the exhaled air of someone else. There also wasn't a lot known about the characteristics of the virus when NYC was hit. NYC absolutely had to shut down when it did in order to stem the tide. For the purposes of comparison, we should probably compare the data from Miami and NYC. However, those cities are in very different phases of the virus. NYC does not seem to be in an upswing, but Miami seems to be.

I live in a city in Central NY State. Our experience with COVID-19 was entirely different from that of NYC, but we certainly didn't get through it unscathed. We wear our masks (for the most part ) and practice social distancing but we still get hotspots when people decide that the mask mandate doesn't apply to them or decide that it is too onerous to comply for one reason or another. We seem to see our greatest outbreaks in manufacturing and warehousing facilities.

My concern with Florida is the sheer number of seniors and people with underlying health conditions juxtaposed against the numbers of people who refuse to wear a mask and/or practice social distancing. Right now, Florida is on the upswing and we don't know how high it will swing nor how many it will take out. The good news is that we have learned things about the virus as it has raged through other nations, states and communities. This has led to slightly better outcomes for patients battling COVID-19 in places like Florida and Texas.

In Florida, the problem with herd immunity (if it's even achievable) is that far too many of the herd are older and in failing health. To achieve it, we will likely lose a large portion of that subset within our herd.
Lets start with your opening statement.

The problem with this is that there is no reason to believe that herd immunity to COVID-19 can be achieved, at all. Some people have recovered and become infected again

That's old news, and proven false by recent studies. They have found that the people who tested "positive" again just had fragments of dead virus in their system, which fooled the test. Here's just one of many.

Scientists from the Korean Centers for Disease Control and Prevention studied 285 Covid-19 survivors who had tested positive for the coronavirus after their illness had apparently resolved, as indicated by a previous negative test result. The so-called re-positive patients weren’t found to have spread any lingering infection, and virus samples collected from them couldn’t be grown in culture, indicating the patients were shedding non-infectious or dead virus particles.

All the latest studies show that almost everyone who recovers from covid 19 develops antibodies to the disease. Antibodies to SARS were found to be good for 2 years. (one reason it never came back) Then you have the t-cell immunes, who fight off the virus with their immune system. You have to test specifically for T-cell immunity, as it does not show up in an antibody test.

New York and Florida are very similar in size, population, and population density. New York has one huge city, while Florida has 3 medium size cities that add up to one NYC.
The purpose in comparing the two in deaths and cases is not about saying who did a better job. When you look at the comparison in new cases, and how New York had a huge amount that peaked and then has fallen to very low numbers, without a spike in new cases, you wonder why this is. The only thing I can conclude from that data is that NY has achieved a high enough level of immunity that the virus has run out of easy targets. Florida has not attained this level yet, so we got a spike after protests and reopening.

NYC was hit first, seeded heavily from European travelers. By the time they locked down it was too far gone. They had s few hundred confirmed cases and probably several thousand asymptomatics and very mild cases that spread the virus all over the city. Basically, they ran a herd immunity test case without knowing it.

Last edited by GoodLife; 07-03-2020 at 06:57 AM.
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Old 07-03-2020, 07:04 AM
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Another thing Sweden and the US have in common: neither country’s citizens are allowed into most European countries without a two week quarantine. Norway and Denmark do not want Swedes entering their countries. Of course, at present, if you want to visit Maine, you have to quarantine for two weeks. I was planning to go there this summer. But now I can’t.

As for “herd immunity,” we will eventually find out, I guess, but it will take time, and it will be subject to waiting changes in recommendations as new information comes out. Meanwhile, I’d rather not be one of those who gets the virus, so I’ll keep on wearing my mask. It’s tough to not know the answers to everything from the beginning, but that’s not how science works.

Quote:
Originally Posted by GoodLife View Post
Some new studies give some signs for hope that this pandemic may run out of steam sooner than we think. But first a couple of graphs.

Sweden vs USA, deaths per million (Sweden = Black USA = Red)​

Attachment 84965

Sweden vs USA cases per million​

Attachment 84966

Both deaths and cases per million look very similar when graphed. Sweden did not lock down economy, close schools, use masks while most of the USA did. Sweden did advise citizens to social distance, but nothing like the shelter at home guidelines issued in USA. Sweden's death rate per million is slightly higher than USA, but the graphs show a very similar rise to a peak and then fall. Cases per day rose quickly in both countries, then flatten and both showing a recent rise. But deaths are falling in both countries, not following the recent rise in cases. (The blip you see in Sweden recent deaths was caused by them adding some covid probable deaths in late June) ​

The reason deaths do not seem to be rising is probably the same for both countries, the new cases being found are mostly younger and asymptomatic, not tested before and in an age group that does not die from the virus frequently.​

Anyway, the graphs and data show something is at work here and it doesn't have much to do with lockdowns etc.​

Now lets look at Florida vs New York.​

Florida vs New York daily deaths (NY = Red FL = Green)​

Attachment 84967

Boy we sure did flatten that curve huh? Good job Florida!​

Florida vs New York daily new cases​

Attachment 84968

Wait a minute! Why are new cases in NY going down while ours are going up? NY opened up a month ago, they had huge Floyd protests there too. Maybe they are just better at reopening than we are, or maybe their protesters and a huge percentage of New Yorkers are immune.​

Recently CDC Director Redfield said this: "Our best estimate right now is that for every case that's reported, there actually are 10 other infections," Dr. Robert Redfield, director of the CDC, said on a call with reporters Thursday.​

OK, so NYC has had 212,000 confirmed cases times 10 = 2,120,000 actual cases if CDC correct. Population of NYC is 8 million or so, so that's about 25% of the population that are immune.​

Several new studies have found another kind of immunity from the virus different from antibodies. New research from Karolinska Institutet and Karolinska University Hospital shows that many people with mild or asymptomatic COVID-19 demonstrate so-called T-cell-mediated immunity to the new coronavirus, even if they have not tested positively for antibodies. According to the researchers, this means that public immunity is probably higher than antibody tests suggest. Our results indicate that roughly twice as many people have developed T-cell immunity compared with those who we can detect antibodies in.”

So some people have such strong T cells that they fight off the virus without producing antibodies. Could be from exposure to other coronaviruses like the common cold. This study estimates there are twice as many T cell immune individuals as there are that have antibodies.

So now you can estimate that over 4 million New York City people would either have antibodies or T cell immunity. That's 50% of the population. Is that enough for herd immunity? It sure looks like it in their graph showing new case numbers dwindling down pretty rapidly.

A team at Stanford lead by Nobel Laureate Michael Levitt have been studying data from countries all over the world and think the virus begins to burn out and run out of hosts when infected individuals + asymptomatics reach a certain threshold. Levitt and colleagues think that the existence of large numbers of invisible cases of individuals who are asymptomatic and are not counted as confirmed cases may explain the non exponential behavior of the pandemic, the known cases can't find new people to infect because the invisible cases have already done so.

Basically, Levitt is saying that the various regions his team are tracking are reaching herd immunity faster and at lower levels than many epidemiologists think likely (60-70%)

"I personally think it's less than 30%" said Levitt.

A recent model by MIT predicts that absent a vaccine, the pandemic will grind on until next spring and that Global cases will rise to 249 million with deaths rising to 1.75 million in the 84 countries they survey.

I hope the Stanford guy is right. New York City data looks like he may be.
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Old 07-03-2020, 08:15 AM
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I tested Michael Levitt's theory that saturation to achieve herd immunity is as low as 30%

I multiplied each state's confirmed cases by 10 for asymptomatics, and then doubled that number for T-cell immune response to get a total of visible and invisible cases.

Then I divided that number by each state's population to get covid 19 saturation percentages.

3 states with highest spikes in new cases

Florida 15% saturation level
Texas 12%
California 7%

3 States with no spikes in new cases

New York 41% saturation level
New Jersey 38%
Massachusetts 31%

I'm starting to think Michael Levitt of Stanford is a very smart guy who deserved every bit of his Nobel Prize.
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Old 07-03-2020, 12:02 PM
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The virus is clearly weakening, too. The cloth masks, bandanas, scarves and dust masks that people are wearing only offer very minimal protection. If this virus was that deadly we would know it. People would be dropping like flies and if that was happening no one would have to order them to stay inside of their houses.

This has been one of the most aggravating, ridiculous, unscientific and costly societal jokes that has ever happened in this country if not the world.
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Old 07-03-2020, 05:03 PM
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The virus is clearly weakening, too. The cloth masks, bandanas, scarves and dust masks that people are wearing only offer very minimal protection. If this virus was that deadly we would know it. People would be dropping like flies and if that was happening no one would have to order them to stay inside of their houses.

This has been one of the most aggravating, ridiculous, unscientific and costly societal jokes that has ever happened in this country if not the world.
Yes, it's a giant clusterfark. Fauci has been a disaster and is a prime example of the Dilbert Principle. Just one 180 degree flip flop after another. You name it, he's been wrong on it. Masks, travel bans, asymptomatic cases etc etc

They knew everything they needed to know back in February after analyzing the Diamond Princess outbreak, contagion vectors, infection rates, asymptomatic cases, death rates, etc

Nobel Prize Winning Professor Explains How 'Scientists Have Failed' Throughout COVID-19 Pandemic - Big League Politics

Here's a nifty graph showing the surge in Florida while death rates plummet.
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Old 07-03-2020, 05:30 PM
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Originally Posted by GoodLife View Post
Yes, it's a giant clusterfark. Fauci has been a disaster and is a prime example of the Dilbert Principle. Just one 180 degree flip flop after another. You name it, he's been wrong on it. Masks, travel bans, asymptomatic cases etc etc

They knew everything they needed to know back in February after analyzing the Diamond Princess outbreak, contagion vectors, infection rates, asymptomatic cases, death rates, etc

Nobel Prize Winning Professor Explains How 'Scientists Have Failed' Throughout COVID-19 Pandemic - Big League Politics

Here's a nifty graph showing the surge in Florida while death rates plummet.
Nobody is interested in the facts though. That's the part that is so incredibly frustrating and stupid about this thing.

I am beginning to think that people are no longer capable of using critical thinking skills. If some "expert" told them to dive lemming like off of a cliff they would do it.
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Old 07-04-2020, 04:56 AM
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Quote:
Originally Posted by GoodLife View Post
Yes, it's a giant clusterfark. Fauci has been a disaster and is a prime example of the Dilbert Principle. Just one 180 degree flip flop after another. You name it, he's been wrong on it. Masks, travel bans, asymptomatic cases etc etc

They knew everything they needed to know back in February after analyzing the Diamond Princess outbreak, contagion vectors, infection rates, asymptomatic cases, death rates, etc

Nobel Prize Winning Professor Explains How 'Scientists Have Failed' Throughout COVID-19 Pandemic - Big League Politics

Here's a nifty graph showing the surge in Florida while death rates plummet.
Suggest you revisit in 3-4 weeks. Takes at least that long for the hospitalizations and then deaths to show. The deaths that are reported now are for infections before the current spike.
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Old 07-04-2020, 06:29 AM
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Good luck and stay safe until then.
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Old 07-04-2020, 06:36 AM
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Suggest you revisit in 3-4 weeks. Takes at least that long for the hospitalizations and then deaths to show. The deaths that are reported now are for infections before the current spike.
Florida surge started early June, almost 1 month ago. CDC puts time from symptoms to death at average of 14 days.

This chart graphs new cases vs deaths offset by 14, 21, and 28 days

florida-death-lag-png

Last edited by GoodLife; 07-04-2020 at 06:42 AM.
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Old 07-04-2020, 06:48 AM
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Well done and well written. Thank you.
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Old 07-04-2020, 06:48 AM
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Compare apples to apples Sweden’s population 10 million us has 330 million and is not as densely populated.
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Old 07-04-2020, 07:19 AM
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Compare apples to apples Sweden’s population 10 million us has 330 million and is not as densely populated.
The graphs comparing the two are cases and deaths per million residents.

Sweden percentage of population living in urban areas is 87%. USA is 80% urban population.

Virus infects people the same way all over the world.
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